The Buffalo Bills will try to extend their five-game winning streak when they travel to Chicago for a meeting with the Bears on Saturday. Buffalo was able to clinch a playoff berth with a 32-29 win over Miami last Saturday, using a last-second field goal to pick up the win. Quarterback Josh Allen ripped apart Miami’s defense, throwing for 304 yards and four touchdowns while also rushing for 77 yards on 10 carries. The Bills are nine-point favorites in the latest Week 16 NFL odds at Caesars Sportsbook. Which Week 16 NFL lines should you target with your Week 16 NFL bets? Before you make any Week 16 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 of the 2022 NFL season on an incredible 157-113 run on top-rated NFL picks that dates back to the 2017 season. The model ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is WAY UP. Now, the model has locked in five confident NFL best bets for Week 16. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 16 NFL picks at SportsLine.
Top Week 16 NFL picksAfter simulating every game 10,000 times, the model is high on the Minnesota Vikings (-3.5) to cover against the New York Giants. Minnesota has been one of the top teams in the NFL this season, and its magical run continued when it recorded the largest comeback win in league history against Indianapolis last week. The Vikings erased a 33-point deficit in a 39-36 victory as kicker Greg Joseph drilled a 40-yard field goal with three seconds remaining in overtime to clinch the NFC North title.Quarterback Kirk Cousins threw for 460 yards and four touchdowns to lead the Vikings. New York only has one win in its last five games and is on the back end of a two-game road trip. The Giants are not in a strong scheduling spot and are facing one of the best teams in the league, which is one reason why the model has Minnesota covering the spread well over 50% of the time. See which other NFL parlay picks to make here.How to make Week 16 NFL parlaysThe model also jumped on four other NFL matchups where it says the line is way off, including a pair of underdogs that have a chance to win outright. You can only see the model’s NFL Week 16 best bets and parlay at SportsLine.
What are the model’s top Week 16 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 16 NFL best bets from a model on a 157-113 run on its top-rated picks, and find out.